Matricellular protein SPARC/osteonectin expression is regulated by DNA methylation in its core promoter region

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Matricellular protein SPARC/osteonectin expression is regulated by DNA methylation in its core promoter region.

BACKGROUND SPARC/osteonectin is an evolutionarily conserved matricellular protein that modulates cell-matrix interaction and cell function. In all vertebrates, SPARC is dynamically expressed during embryogenesis. However, the precise function of SPARC and the regulatory elements required for its expression in particular during early embryogenesis are largely unknown. RESULTS The present study...

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ژورنال

عنوان ژورنال: Developmental Dynamics

سال: 2015

ISSN: 1058-8388

DOI: 10.1002/dvdy.24267